Article
Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection.
Infection and immunity - 1 Feb 1996
Pope C D, O'Connell W, Cianciotto N P
Abstract excerpt
Legionella pneumophila, a parasite of macrophages and protozoa, requires iron for optimal extracellular and intracellular growth. However, its mechanisms of iron acquisition remain uncharacterized. Using mini-Tn10 mutagenesis, we isolated 17 unique L. pneumophila strains which appeared to be defective for iron acquisition and assimilation. Eleven of these mutants were both sensitive to the iron chelator...
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