Article
Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore.
Journal of bacteriology - 1 Apr 2011
Chatfield Christa H, Mulhern Brendan J, Burnside Denise M, Cianciotto Nicholas P
Abstract excerpt
Gram-negative Legionella pneumophila produces a siderophore (legiobactin) that promotes lung infection. We previously determined that lbtA and lbtB are required for the synthesis and secretion of legiobactin. DNA sequence and reverse transcription-PCR (RT-PCR) analyses now reveal the presence of an iron-repressed gene (lbtU) directly upstream of the lbtAB-containing operon. In silico analysis predicted that LbtU...
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