Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tetranucleotide repeat polymorphism D21S1245 demonstrates hypermutability in germline and somatic cells.

Human molecular genetics - 1 Jul 1995

Talbot C C, Avramopoulos D, Gerken S, Chakravarti A, Armour J A, Matsunami N, White R, Antonarakis S E

Abstract excerpt

Six novel polymorphic short sequence repeats were identified and localized on the linkage map of human chromosome 21 by genotyping the CEPH reference pedigrees. One of these markers, the tetrameric (AAAG)n repeat D21S1245, was found to be hypermutable. In the DNAs from lymphoblastoid cell lines of members of the 40 CEPH families a total of 18 new alleles were detected. These new alleles, sometimes appearing in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Genetic Linkage

Share to Genetic Markers

Share to Molecular Sequence Data

Share to Polymorphism, Genetic

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 8528208
DOI: 10.1093/hmg/4.7.1193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tetranucleotide repeat polymorphism D21S1245 demonstrates hypermutability in germline and somatic cells.PMID 8528208Read ↗

Mutation of human short tandem repeats.Semantic proximity Read ↗

Single-molecule analysis of the hypermutable tetranucleotide repeat locus D21S1245 through sperm genotyping: a heterogeneous pattern of mutation but no clear male age effect.Semantic proximity Read ↗

A polymorphic X-linked tetranucleotide repeat locus displaying a high rate of new mutation: implications for mechanisms of mutation at short tandem repeat loci.Semantic proximity Read ↗

Linkage mapping of the highly informative DNA marker D21S156 to human chromosome 21 using a polymorphic GT dinucleotide repeat.Semantic proximity Read ↗

Linkage mapping of D21S171 to the distal long arm of human chromosome 21 using a polymorphic (AC)n dinucleotide repeat.Semantic proximity Read ↗

Characterization of mutations and sequence variants in the D21S11 locus by next generation sequencing.Semantic proximity Read ↗

D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21.Semantic proximity Read ↗

New alleles at microsatellite loci in CEPH families mainly arise from somatic mutations in the lymphoblastoid cell lines.Semantic proximity Read ↗

A collection of tri- and tetranucleotide repeat markers used to generate high quality, high resolution human genome-wide linkage maps.Semantic proximity Read ↗

The mutational spectrum of human autosomal tetranucleotide microsatellites.Semantic proximity Read ↗

[Identification of three rare allele: D21S11*24.2, D7S820*9.1 and HUMFGA*19.2 in Polish population].Semantic proximity Read ↗

A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.