Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.

Abstract excerpt

The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras. In schwannoma cell lines from patients with neurofibromatosis, loss of neurofibromin was previously shown to be associated with impaired regulation of GTP-Ras. Our analysis of other neural...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Meningioma and schwannoma management
• Share to Neuroblastoma Research and Treatments
• Share to Neurofibromatosis and Schwannoma Cases