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Article

Lack of NF1 expression in a sporadic schwannoma from a patient without neurofibromatosis.

Journal of neuro-oncology - 1 Jan 1995

Gutmann D H, Silos-Santiago I, Geist R T, Daras M, Rutkowski J L

Abstract excerpt

The neurofibromatosis type 1 (NF1) gene encodes a tumor suppressor protein, neurofibromin, which is expressed at high levels in Schwann cells and other adult tissues. Loss of NF1 expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 and its loss is associated with increased proliferation of these cells. In this report, we describe downregulation of NF1 expression in a...

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Identifiers

PMID: 8543966
DOI: 10.1007/BF01057754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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