Article
Lack of NF1 expression in a sporadic schwannoma from a patient without neurofibromatosis.
Journal of neuro-oncology - 1 Jan 1995
Gutmann D H, Silos-Santiago I, Geist R T, Daras M, Rutkowski J L
Abstract excerpt
The neurofibromatosis type 1 (NF1) gene encodes a tumor suppressor protein, neurofibromin, which is expressed at high levels in Schwann cells and other adult tissues. Loss of NF1 expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 and its loss is associ...
Topics
- Adult
- Base Sequence
- Blotting, Northern
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Genes, Neurofibromatosis 1
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Molecular Sequence Data
- Mutation
- Neurilemmoma
- Polymerase Chain Reaction
- RNA Probes
- RNA, Neoplasm
- Spinal Cord Neoplasms
- Tumor Cells, Cultured