Article
Neurofibromatosis type 1 gene mutations in neuroblastoma.
Nature genetics - 1 Jan 1993
The I, Murthy A E, Hannigan G E, Jacoby L B, Menon A G, Gusella J F, Bernards A
Abstract excerpt
The introduction of human chromosome 17 suppresses the tumourigenicity of a neuroblastoma cell line in the absence of any effects on in vitro growth and the neurofibromatosis type 1 (NF1) gene may be responsible. Here we report that 4 out of 10 human neuroblastoma lines express little or no neurofibromin and that two of these lines show evidence of NF1 mutations, providing further proof that NF1 mutations occur...
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