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Article

Assembly of the U2 small nuclear ribonucleoprotein from Trypanosoma brucei. A mutational analysis.

The Journal of biological chemistry - 25 Jun 1993

Günzl A, Cross M, Palfi Z, Bindereif A

Abstract excerpt

trans-Splicing in trypanosomes requires the functions of U2 and U4/U6 small nuclear (sn) RNPs. We have analyzed protein binding and assembly of the Trypanosoma brucei U2 snRNP, using specific antibodies against U2 snRNP proteins and in vitro reconstitution assays of U2 deletion derivatives and human-trypanosome hybrid RNAs. Stable binding of both the U2-specific 40-kDa and the common proteins requires only the...

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PMID: 8514772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Assembly of the U2 small nuclear ribonucleoprotein from Trypanosoma brucei. A mutational analysis.PMID 8514772Read ↗

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