Exon/intron structure of the human <i>AF‐4</i> gene, a member of the <i>AF</i>‐4/<i>LAF</i>‐4/<i>FMR</i>‐2 gene family coding for a nuclear protein with structural alterations in acute leukaemia

Abstract excerpt

The AF-4 gene on human chromosome 4q21 is involved in reciprocal translocations to the ALL-1 gene on chromosome 11q23, which are associated with acute lymphoblastic leukaemias. A set of recombinant phage carrying genomic fragments for the coding region and flanking sequences of the AF-4 gene were isolated. Phage inserts were assembled into four contigs with 21 exons, and an intron phase map was produced enabling...

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