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Article

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias

15 Jan 1996

Abstract excerpt

A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs). In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein. AF-4 and LAF-4 are homologous...

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Identifiers

PMID: 8555498
DOI: 10.1182/blood.v87.2.734.bloodjournal872734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemiasPMID 8555498Read ↗

The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4Semantic proximity Read ↗

Exon/intron structure of the human <i>AF‐4</i> gene, a member of the <i>AF</i>‐4/<i>LAF</i>‐4/<i>FMR</i>‐2 gene family coding for a nuclear protein with structural alterations in acute leukaemiaSemantic proximity Read ↗

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.Semantic proximity Read ↗

Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele.Semantic proximity Read ↗

Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesisSemantic proximity Read ↗

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex InteractionSemantic proximity Read ↗

Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.Semantic proximity Read ↗

Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.Semantic proximity Read ↗

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneSemantic proximity Read ↗

AF4/FEL, a gene involved in infant leukemia: sequence variations, gene structure, and possible homology with a genomic sequence on 5q31.Semantic proximity Read ↗

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.Semantic proximity Read ↗

A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cellsSemantic proximity Read ↗

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