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Article

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.

Endocrinology - 1 Jun 1993

Lin D, Black S M, Nagahama Y, Miller W L

Abstract excerpt

Cytochrome P450c17 (EC 1.14.99.9) catalyzes both 17 alpha-hydroxylase and 17,20-lyase activities in mammalian steroidogenesis and also has some 16 alpha-hydroxylase activity. The ratio of 17 alpha-hydroxylase to 17,20-lyase activity differs in the adrenal and testis and is developmentally regulat...

Topics

Aldehyde-Lyases
Animals
Aryl Hydrocarbon Hydroxylases
Base Sequence
Cell Line, Transformed
Cytochrome P-450 Enzyme System
Cytochrome Reductases
Cytochromes b5
Humans
Molecular Probes
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serine

Steroid 16-alpha-Hydroxylase

Steroid 17-alpha-Hydroxylase

Steroid Hydroxylases

Trout

Source

Identifiers

PMID: 8504753
DOI: 10.1210/endo.132.6.8504753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8504753-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.PMID 8504753Read ↗

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