Article
The impaired in vitro production of interleukin-2 in HIV infection is negatively correlated to the number of circulating CD4+DR+ T cells and is reversed by allowing T cells to rest in culture: arguments for in vivo CD4+ T cell activation.
Clinical immunology and immunopathology - 1 Jun 1993
Lees O, Ramzaoui S, Gilbert D, Borsa F, Humbert G, Leblanc D, Lagarde M, Tron F
Abstract excerpt
In HIV infection, several arguments suggest a certain degree of CD4+ T cell activation which might contribute to lymphocyte dysfunctions. To investigate this possibility, we determined the phenotypes of circulating CD4+ T cells using monoclonal antibodies directed to activation markers and examin...
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