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Article

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1 Jan 1993

Abstract excerpt

The role of insulin-like growth factor I (IGF-I) in the growth and development of prostate cancer was studied using established human prostate cancer cell lines. Under steroid and growth factor-free culture conditions, IGF-I significantly stimulated the androgen-independent cell lines PC-3 and DU-145 to incorporate [3H]thymidine into DNA, while the androgen-dependent cell line, LNCaP, was not affected. However,...

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PMID: 8488157
DOI: 10.1002/pros.2990220307

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