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Article

Template activating factor I, a novel host factor required to stimulate the adenovirus core DNA replication

1 May 1993

Abstract excerpt

The adenovirus (Ad) genome in virion exists in the form of the Ad core, which is a complex of Ad DNA and viral basic proteins. The Ad core supported only initiation and limited elongation in DNA replication in a cell-free system which was developed for DNA replication of naked Ad DNA. We found that addition of a cytoplasmic fraction from uninfected HeLa cells on the top of the system stimulated Ad core DNA...

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PMID: 8486711
DOI: 10.1016/s0021-9258(18)82238-4

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