Article
DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene.
Genomics - 1 Apr 1993
Schwenger B, Schöber S, Simon D
Abstract excerpt
Deficiency of uridine monophosphate synthase (DUMPS) is a monogenic autosomal recessive disorder in cattle, resulting in early embryonic death of homozygous offspring. To identify the mutation responsible for DUMPS, liver RNA from identified, DUMPS heterozygous animals from the Holstein and Red H...
Topics
- Animals
- Base Sequence
- Cattle
- Cattle Diseases
- DNA
- DNA Mutational Analysis
- Female
- Genotype
- Heterozygote
- Male
- Molecular Sequence Data
- Multienzyme Complexes
- Orotate Phosphoribosyltransferase
- Orotidine-5'-Phosphate Decarboxylase
- Pedigree
- Point Mutation
- Polymerase Chain Reaction
- Purine-Pyrimidine Metabolism, Inborn Errors