ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.

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Article

ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.

Oncogene - 1 May 1993

Kelliher M A, Weckstein D J, Knott A G, Wortis H H, Rosenberg N

Abstract excerpt

Mice reconstituted with BCR/ABL-infected 5-fluorouracil-treated bone marrow are considered a model system for human chronic myelogenous leukemia, a malignancy that arises in hematopoietic stem cells. These animals develop multiple types of hematopoietic tumors, which could arise either from undif...

Topics

Animals
Base Sequence
Bone Marrow
Cell Transformation, Neoplastic
Fluorouracil
Fusion Proteins, bcr-abl
Genes, abl
Hematopoietic Stem Cells
Interleukin-3
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphoma
Macrophage-1 Antigen
Mice
Molecular Sequence Data
Phenotype
Proviruses

Source

Open in PubMed

Identifiers

PMID: 8479746

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8479746-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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