Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.

Oncogene - 1 May 1993

Kelliher M A, Weckstein D J, Knott A G, Wortis H H, Rosenberg N

Abstract excerpt

Mice reconstituted with BCR/ABL-infected 5-fluorouracil-treated bone marrow are considered a model system for human chronic myelogenous leukemia, a malignancy that arises in hematopoietic stem cells. These animals develop multiple types of hematopoietic tumors, which could arise either from undifferentiated cells that mature during tumor development or from progenitors committed to different lineages. To examine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Bone Marrow
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Lymphoma

Share to Molecular Sequence Data

Share to Phenotype

Source

Identifiers

PMID: 8479746

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.PMID 8479746Read ↗

Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.Semantic proximity Read ↗

Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow.Semantic proximity Read ↗

Fluorouracil selectively spares acute myeloid leukemia cells with long- term growth abilities in immunodeficient mice and in cultureSemantic proximity Read ↗

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fateSemantic proximity Read ↗

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.Semantic proximity Read ↗

MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model.Semantic proximity Read ↗

Activation of quiescent ABL-transduced hemopoietic stem cells.Semantic proximity Read ↗

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene.Semantic proximity Read ↗

Biological properties and growth in SCID mice of a new myelogenous leukemia cell line (KBM-5) derived from chronic myelogenous leukemia cells in the blastic phase.Semantic proximity Read ↗

Blast crisis in a murine model of chronic myelogenous leukemia.Semantic proximity Read ↗

Transformation of murine pre-B-lymphocytes by v-erb-B: progression to growth factor independence and tumorigenicity.Semantic proximity Read ↗

BCR/ABL P210 and P190 cause distinct leukemia in transgenic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.