Biosynthesis of the pradimicin family of antibiotics. I. Generation and selection of pradimicin-nonproducing mutants.

doi:10.7164/antibiotics.46.412

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Article

Biosynthesis of the pradimicin family of antibiotics. I. Generation and selection of pradimicin-nonproducing mutants.

The Journal of antibiotics - 1 Mar 1993

Furumai T, Kakinuma S, Yamamoto H, Komiyama N, Suzuki K, Saitoh K, Oki T

Abstract excerpt

Germinated spores of Actinomadura verrucosospora subsp. neohibisca E-40, a high pradimicins producer, were mutagenized by N-methyl-N'-nitro-N-nitrosoguanidine and/or UV treatment. Thirty-seven mutants which did not produce pradimicin were selected to test for cosynthesis ability, and classified i...

Topics

Actinomycetaceae
Antibiotics, Antineoplastic
Antifungal Agents
Fermentation
Methylnitronitrosoguanidine
Mutation

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