Article
Biosynthesis of the pradimicin family of antibiotics. II. Fermentation, isolation and structure determination of metabolites associated with the pradimicins biosynthesis.
The Journal of antibiotics - 1 Mar 1993
Tsuno T, Yamamoto H, Narita Y, Suzuki K, Hasegawa T, Kakinuma S, Saitoh K, Furumai T, Oki T
Abstract excerpt
Ten metabolites produced by 4 mutants derived from Actinomadura verrucosospora subsp. neohibisca E-40, a high pradimicins producer, were isolated and their structures were determined. Strain JN-219 produced 3 novel analogs of the pradimicin A aglycone, i.e. 11-O-demethyl-7-methoxypradinone II and 11-O-demethylpradinones I and II together with a known aglycone analog, pradinone I, while the metabolites from strain...
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