Article
Pradimicins M, N, O and P, new dihydrobenzo[a]naphthacenequinones produced by blocked mutants of Actinomadura hibisca P157-2.
The Journal of antibiotics - 1 Nov 1990
Sawada Y, Tsuno T, Yamamoto H, Nishio M, Konishi M, Oki T
Abstract excerpt
Four blocked mutants which accumulated new dihydrobenzo[a]naphthacenequinone metabolites, designated pradimicins M, N, O and P, have been isolated from cultures of mutants of Actinomadura hibisca P157-2 resulting from treatment with N-methyl-N'-nitro-N-nitrosoguanidine. The structures of the four compounds were determined by spectral analysis. Pradimicins N, O and P contain D-alanine, while pradimicin M does not....
Topics
- Anthracyclines
- Antibiotics, Antineoplastic
- Antifungal Agents
- Chromatography, Thin Layer
- Fermentation
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Molecular Structure
- Mutation
- Nocardiaceae