Article
Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100.
Metabolism: clinical and experimental - 1 Feb 1993
Schmidt E B, Illingworth D R, Bacon S, Russell S J, Thatcher S R, Mahley R W, Weisgraber K H
Abstract excerpt
Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which an amino acid substitution in apolipoprotein B-100 results in low-density lipoprotein (LDL) particles that bind poorly to the LDL receptor and accumulate in plasma. Patients with FDB described to date have been heterozygous for this disorder, and their plasma contains both normal and...
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