Article
Decreased resistance against in vitro oxidation of LDL from patients with familial defective apolipoprotein B-100.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Mar 1994
Stalenhoef A F, Defesche J C, Kleinveld H A, Demacker P N, Kastelein J J
Abstract excerpt
Familial defective apolipoprotein B-100 (FDB) is caused by a mutation in the receptor-binding region of apolipoprotein B-100, the structural protein of the low-density lipoprotein (LDL) particle. We studied the effect of this mutation on the composition and susceptibility to oxidative modification of LDL in patients with FDB. Twenty Dutch carriers of the mutation identified in a family study were matched with 20...
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