Article
The affinity of low-density lipoproteins and of very-low-density lipoprotein remnants for the low-density lipoprotein receptor in homozygous familial defective apolipoprotein B-100.
Atherosclerosis - 1 Jun 1995
Gallagher J J, Myant N B
Abstract excerpt
We have identified two familial defective apo B-100 (FDB) homozygotes by DNA sequencing and have measured affinity of low-density lipoproteins (LDL) and very-low-density lipoprotein (VLDL) remnants for the LDL receptor in vitro. The patients were a 66-year-old man with coronary heart disease (pla...
Topics
- Aged
- Apolipoprotein B-100
- Apolipoproteins B
- Base Sequence
- Coronary Disease
- Female
- Homozygote
- Humans
- Hyperlipoproteinemia Type II
- Lipoproteins, LDL
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Receptors, Lipoprotein