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Article

Bicyclomycin sensitivity and resistance affect Rho factor-mediated transcription termination in the tna operon of Escherichia coli.

Journal of bacteriology - 1 Aug 1995

Yanofsky C, Horn V

Abstract excerpt

The growth-inhibiting drug bicyclomycin, known to be an inhibitor of Rho factor activity in Escherichia coli, was shown to increase basal level expression of the tryptophanase (tna) operon and to allow growth of a tryptophan auxotroph on indole. The drug also relieved polarity in the trp operon and permitted growth of a trp double nonsense mutant on indole. Nine bicyclomycin-resistant mutants were isolated and...

Topics

Anti-Bacterial Agents
Bridged Bicyclo Compounds
Bridged Bicyclo Compounds, Heterocyclic
Drug Resistance, Microbial
Escherichia coli
Gene Expression
Gene Expression Regulation, Bacterial
Genetic Complementation Test
Mutation
Operon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Bacterial

Rho Factor

Transcription, Genetic

Tryptophanase

Source

Open in PubMed Open full text

Identifiers

PMID: 7543478
DOI: 10.1128/jb.177.15.4451-4456.1995
PMCID: PMC177196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7543478-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Bicyclomycin sensitivity and resistance affect Rho factor-mediated transcription termination in the tna operon of Escherichia coli.PMID 7543478Read ↗

Phenotypic characterization of a comprehensive set of bicyclomycin-resistant mutants.Semantic proximity Read ↗

The bicyclomycin sensitivities of 38 bicyclomycin-resistant mutants of transcription termination protein rho and the location of their mutations support a structural model of rho based on the F(1) ATPase.Semantic proximity Read ↗

Loss of overproduction of polypeptide release factor 3 influences expression of the tryptophanase operon of Escherichia coli.Semantic proximity Read ↗

Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli.Semantic proximity Read ↗

The molecular basis for the mode of action of bicyclomycin.Semantic proximity Read ↗

Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation.Semantic proximity Read ↗

tRNA(Trp) translation of leader peptide codon 12 and other factors that regulate expression of the tryptophanase operon.Semantic proximity Read ↗

Transcription termination factor Rho is essential for Micrococcus luteus.Semantic proximity Read ↗

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin.Semantic proximity Read ↗

In vitro characterization of transcription termination factor Rho from Escherichia coli rho(nusD) mutants.Semantic proximity Read ↗

Role of ribosome release in regulation of tna operon expression in Escherichia coli.Semantic proximity Read ↗

Inhibition of expression of the tryptophanase operon in Escherichia coli by extrachromosomal copies of the tna leader region.Semantic proximity Read ↗

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