Article
[Mutation screening of GCK gene in Chinese early-onset diabetes population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2005
Zheng Tai-shan, Wu Song-hua, Yang Zhen, Lu Hui-juan, Xiang Kun-san
Abstract excerpt
OBJECTIVE: To investigate the prevalence of mutations and sequence variations of glucokinase gene GCK in Chinese early-onset diabetes population. METHODS: The study was conducted in 174 unrelated Chinese residents, including 80 nondiabetic controls, 94 probands of early-onset diabetes pedigree. Direct sequencing was performed to screen all 10 exons of glucokinase gene, including promoter and exon/intron...
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