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Article

Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation.

The Journal of clinical investigation - 1 Mar 1993

Zoppi S, Wilson C M, Harbison M D, Griffin J E, Wilson J D, McPhaul M J, Marcelli M

Abstract excerpt

We have characterized the molecular defect causing androgen resistance in two 46,XY siblings with complete testicular feminization. Although binding studies in genital skin fibroblasts showed a reduced Bmax, an increased dissociation rate of ligand, and an 8S peak of dihydrotestosterone binding on sucrose density gradient centrifugation, no immunoreactive androgen receptor (AR) was detected in immunoblots using...

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Identifiers

PMID: 8450040
DOI: 10.1172/JCI116269
PMCID: PMC288066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation.PMID 8450040Read ↗

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