Article
Functional characterization of naturally occurring mutant androgen receptors from subjects with complete androgen insensitivity.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1990
Brown T R, Lubahn D B, Wilson E M, French F S, Migeon C J, Corden J L
Abstract excerpt
Mutations in the androgen receptor (AR) are thought to cause complete androgen insensitivity (CAIS) in 46,XY human subjects who have a female phenotype despite normal adult male concentrations of plasma testosterone. Assays of AR binding in cultured skin fibroblasts from subjects with CAIS show either an apparent absence of AR (AR-) or normal levels of AR (AR+) binding. In several subjects with CAIS, AR-, no...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- DNA
- Fibroblasts
- Humans
- Immunoblotting
- Male
- Molecular Sequence Data