Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg----Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function.

doi:10.1210/jcem-73-2-318

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Article

Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg----Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function.

The Journal of clinical endocrinology and metabolism - 1 Aug 1991

Marcelli M, Tilley W D, Zoppi S, Griffin J E, Wilson J D, McPhaul M J

Abstract excerpt

Analysis of the nucleotide sequence of the coding segment of the androgen receptor gene in a patient (N105) with the receptor-negative form of complete testicular feminization has revealed a single substitution (CGC----TGC) at nucleotide 2476. This alteration results in the conversion of an arginine at amino acid 772 to a cysteine. Introduction of this mutation into an androgen receptor cDNA and transfection of...

Topics

Androgen-Insensitivity Syndrome
Arginine
Base Sequence
Cell Line
Cysteine
Dihydrotestosterone
Drug Resistance
Female
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Oligonucleotide Probes

RNA, Messenger

Receptors, Androgen

Transfection

Source

Open in PubMed

Identifiers

PMID: 1856263
DOI: 10.1210/jcem-73-2-318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1856263-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg----Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function.PMID 1856263Read ↗

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Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes.Semantic proximity Read ↗

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