Article
Envelope-binding domain in the cationic amino acid transporter determines the host range of ecotropic murine retroviruses
1 Apr 1993
Abstract excerpt
Infection of rodent cells by ecotropic type C retroviruses requires the expression of a cationic amino acid transporter composed of multiple membrane-spanning domains. By exchanging portions of cDNAs encoding the permissive mouse and nonpermissive human transporters and examining their abilities to specify virus infection upon expression in human 293 cells, we have identified the amino acid residues in the...
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