Article
Mammalian U6 small nuclear RNA undergoes 3' end modifications within the spliceosome.
Molecular and cellular biology - 1 Mar 1993
Tazi J, Forne T, Jeanteur P, Cathala G, Brunel C
Abstract excerpt
Mammalian U6 small nuclear RNA (snRNA) is heterogeneous with respect to the number of 3' terminal U residues. The major form terminates with five U residues and a 2',3' cyclic phosphate. Because of the presence in HeLa cell nuclear extracts of a terminal uridylyl transferase, a minor form of U6 snRNA is elongated, producing multiple species containing up to 12 U residues. In this study we have used glycerol...
Topics
- Base Composition
- Cell Nucleus
- Cell-Free System
- Genetic Variation
- HeLa Cells
- Humans
- Macromolecular Substances
- Nucleic Acid Conformation
- RNA Precursors
- RNA Splicing
- RNA, Small Nuclear
- Ribonucleoprotein, U4-U6 Small Nuclear
- Spliceosomes
- Transcription, Genetic