Article
Direct evidence that human follicular dendritic cells (FDC) rescue germinal centre B cells from death by apoptosis.
Clinical and experimental immunology - 1 Feb 1993
Lindhout E, Mevissen M L, Kwekkeboom J, Tager J M, de Groot C
Abstract excerpt
It is supposed that FDC have a pivotal role in the rescue of germinal centre (GC) B lymphocytes from apoptosis. However, formal proof for this hypothesis has not as yet been presented. In the present study FDC and GC B cells were isolated from human tonsils and cultured. When brought into culture FDC and B cells rapidly formed spherical clusters. T cells were not observed inside these clusters. At different time...
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