Article
The 22K variant of rat prolactin: evidence for identity to prolactin-(1-173), storage in secretory granules, and regulated release.
Endocrinology - 1 Feb 1993
Anthony P K, Stoltz R A, Pucci M L, Powers C A
Abstract excerpt
Western blot analyses of the rat pituitary have detected a 22K PRL variant distinct from intact PRL (25K). We recently reported that glandular kallikrein (GK), an estrogen-induced lactotroph protease, can process PRL in vitro from a 25K form to a 22K form in a thiol-dependent cleavage at Arg174-A...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Western
- Bromocriptine
- Cysteamine
- Cytoplasmic Granules
- Diethylstilbestrol
- Female
- Genetic Variation
- Immune Sera
- In Vitro Techniques
- Kallikreins