Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.

doi:10.1677/jme.0.0050061

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.

Journal of molecular endocrinology - 1 Aug 1990

Sawa T, Ohgaku S, Morioka H, Yano S

Abstract excerpt

Two insulin genes of the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus, were isolated and characterized to examine the hypothesis that these genes are structurally different from those of normal mice. The NON mouse was found to have two non-allelic insulin...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Chromosome Deletion
Cloning, Molecular
Diabetes Mellitus, Type 2
Disease Models, Animal
Gene Expression Regulation
Gene Library
Insulin
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Mutant Strains

Molecular Sequence Data

Proinsulin

Protein Precursors

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 2397023
DOI: 10.1677/jme.0.0050061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2397023-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.PMID 2397023Read ↗

Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos.Semantic proximity Read ↗

Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.Semantic proximity Read ↗

Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects.Semantic proximity Read ↗

Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes.Semantic proximity Read ↗

Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo.Semantic proximity Read ↗

Pathophysiology of non-insulin-dependent diabetes and the search for candidate genes: dangerous liaisons?Semantic proximity Read ↗

The Genetics of Human Noninsulin-Dependent (Type 2) Diabetes MellitusSemantic proximity Read ↗

[Molecular genetics of non insulin dependent diabetes mellitus].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.