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Article

Unsuitability of multinucleated human blastomeres for preimplantation genetic diagnosis

1 Jul 1993

Abstract excerpt

Multinucleated blastomeres (MNBs) were detected in 30.4% of 230 cleaved but subsequently arrested human embryos, and in 66.7% of 21 cleaved embryos rejected after preimplantation genetic diagnosis. A total of 71 MNBs from both groups of embryos was analysed by fluorescence in-situ hybridization (FISH) using simultaneous X and Y chromosome detection. The sex chromosome analyses of these MNBs suggests the existence...

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Share to Chromosomal and Genetic Variations
Share to Genomic variations and chromosomal abnormalities
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PMID: 8408497
DOI: 10.1093/oxfordjournals.humrep.a138204

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