Influence of debrisoquine oxidation phenotype on exercise tolerance and subjective fatigue after metoprolol and atenolol in healthy subjects.

doi:10.1111/j.1365-2125.1991.tb05551.x

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Article

Influence of debrisoquine oxidation phenotype on exercise tolerance and subjective fatigue after metoprolol and atenolol in healthy subjects.

British journal of clinical pharmacology - 1 Apr 1991

Lewis R V, Ramsay L E, Jackson P R, Yeo W W, Lennard M S, Tucker G T

Abstract excerpt

1. The effects of single doses of metoprolol 50 mg, metoprolol 100 mg and atenolol 100 mg on exercise tolerance were compared with placebo in a double-blind random cross-over study in 12 healthy subjects. Nine subjects were extensive metabolisers of debrisoquine, and three were poor metabolisers....

Topics

Adult
Atenolol
Debrisoquin
Fatigue
Female
Humans
Male
Metoprolol
Oxidation-Reduction
Phenotype
Physical Endurance

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