Human Hydroxyindole- <i>O</i> -Methyltransferase: Presence of LINE-1 Fragment in a cDNA Clone and Pineal mRNA

Abstract excerpt

Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the last step in the synthesis of the pineal hormone melatonin. In this study, an HIOMT clone was isolated from a human pineal cDNA library using synthetic oligonucleotide probes based on the bovine HIOMT sequence. The human sequence is unusual because it contains a 3' fragment (84 bp) of the LINE-1 sequence, a highly repetitive sequence in the human genome and...

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