Article
Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease.
Cancer research - 15 Jun 1995
Frazer I H, Leippe D M, Dunn L A, Liem A, Tindle R W, Fernando G J, Phelps W C, Lambert P F
Abstract excerpt
The human papillomavirus (HPV) oncogenes, E6 and E7, are believed to contribute to the development of cervical cancers in women infected with certain HPV genotypes, most notably HPV-16 and HPV-18. Given their expression in tumor tissue, E6 and E7 have been implicated as potential tumor-specific a...
Topics
- Amino Acid Sequence
- Animals
- Antibody Formation
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Eye Neoplasms
- Female
- Genes, Viral
- Genotype
- Humans
- Hypersensitivity, Delayed
- Immune Tolerance
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Molecular Sequence Data
- Oncogene Proteins, Viral
- Papillomaviridae