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Article

Prognostic significance of human papillomavirus genomes (type‐16, ‐18) and aberrant expression of p53 protein in human esophageal cancer

8 May 1993

Abstract excerpt

The presence and distribution of human papillomavirus (HPV) DNA or of increased expression of the p53 protein were determined in 71 patients with esophageal squamous-cell carcinoma (SCC) by in situ hybridization with biotinylated DNA probes for HPV-16, -18, -31 and -33, and immunohistochemical techniques using antibody to p53 protein. Of 71 patients from Kochi prefecture, 24 (Group I) were positive for HPV DNA,...

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PMID: 8387463
DOI: 10.1002/ijc.2910540211

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