Article
Expression of p21/WAF-1, status of apoptosis and p53 mutation in esophageal squamous cell carcinoma with HPV infection.
Pathology international - 1 Jul 2002
Hasegawa Makoto, Ohoka Izuru, Yamazaki Kazuto, Hanami Kyota, Sugano Isamu, Nagao Toshitaka, Asoh Akira, Wada Nobuaki, Nagao Koichi, Ishida Yasuo
Abstract excerpt
Human papilloma virus (HPV) is regarded as a causative carcinogenic agent in anogenital squamous cell carcinoma (SCC), but there is controversy about its etiologic role in esophageal SCC (ESCC). In this study, we attempted to clarify whether HPV infection plays a crucial role in the development of ESCC by analysis of multiple factors. These included: detection of HPV DNA; evaluation of immunohistochemical assays...
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