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Article

Attenuation of the neuropathogenic equine herpesvirus type 1 strain Ab4p in hamsters by a single amino acid mutation (D752N) in viral DNA polymerase ORF30.

The Journal of veterinary medical science - 1 Dec 2024

Nishimura Fuka, Fukushi Noriko, Sakai Hiroki, Fukushi Hideto

Abstract excerpt

Equine herpesvirus type 1 (EHV-1) causes abortion, respiratory infection, and neurological diseases (equine herpesvirus myeloencephalopathy) in horses. A single nucleotide polymorphism (SNP) associated with a single amino acid in the DNA polymerase gene (ORF30, in which D752 is neuropathogenic and N752 is non-neuropathogenic) of EHV-1 has been associated with neuropathogenicity in horses. We constructed an EHV-1...

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Identifiers

PMID: 39384384
DOI: 10.1292/jvms.24-0338
PMCID: PMC11612248

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