Article
Prostaglandin E2-induced changes in the phenotype, morphology, and lytic activity of IL-2-activated natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1993
Linnemeyer P A, Pollack S B
Abstract excerpt
During pregnancy, many large granular NK lineage cells that are recognized by mAb 4H12 accumulate at uterine implantation sites. Similar large, granular, 4H12+ NK cells accumulate during the 2nd wk of culture of IL-2-activated NK cells. Inasmuch as uterine NK cell lytic activity is suppressed during pregnancy, apparently due to the effects of PGE2, we have analyzed the effect of PGE2 on the phenotype, morphology,...
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