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Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals

1 May 1996

Abstract excerpt

Epstein-Barr virus infects resting B cells in vitro and activates them to continuously proliferating lymphoblasts. Activation is essential for the virus to convert its linear genome to the covalently closed circular episomal form in which it persists in proliferating cells. However, in vivo, Epstein-Barr virus persists in resting B cells. We found that in these cells also the virus is present as an episome,...

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PMID: 8627812
DOI: 10.1128/jvi.70.5.3286-3289.1996

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