Article
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.
Science (New York, N.Y.) - 10 Sept 1993
Devary Y, Rosette C, DiDonato J A, Karin M
Abstract excerpt
Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine...
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