Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair

Abstract excerpt

Activation of transcription factors plays a pivotal role in many signal transduction pathways. Of particular interest is NF-kappaB, which is present in the cytoplasm in an inactive form, where it can be activated in response to many different stress conditions such as infection, inflammation, heat shock etc. It has also been associated with apoptosis and tissue repair. Modulation of signal transduction events...

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