Article
The stellate cells phenotypic transformation in the CCl4- injured liver fibrosis of ICR mice: their desmin immunoreactivity and vitamin A storage.
The Kobe journal of medical sciences - 1 Feb 1993
Lukita-Atmadja W, Subowo
Abstract excerpt
To elucidate the process of phenotypic transformation of stellate cells which were responsible in the production of collagen fibers, ICR mice were injected subcutaneously with CCl4 twice weekly for 5 weeks and the livers were examined by light and electron microscopy every week. Stellate cells were detected by desmin immunoreaction and vitamin A-autofluorescence. In the first week, following cell necrosis in the...
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