North-American Twins With IDDM: Genetic, Etiological, and Clinical Significance of Disease Concordance According to Age, Zygosity, and the Interval After Diagnosis in First Twin

Abstract excerpt

In 224 twin pairs (132 monozygotic, 86 dizygotic, and 6 of uncertain zygosity) in whom the index twin had developed IDDM before 30 yr of age, 51 of the co-twins (38 monozygotic, 10 dizygotic, and 3 of uncertain zygosity) subsequently became diabetic. On the basis of concordance ratios, which were significantly discrepant (P < 0.01) between monozygotic and dizygotic twins, the substantial genetic role in IDDM...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mast cells and histamine
• Share to Parkinson's Disease Mechanisms and Treatments
• Share to RNA regulation and disease