Hereditary predisposition to cancer.

doi:10.1111/j.1749-6632.1997.tb48593.x

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Article

Hereditary predisposition to cancer.

Annals of the New York Academy of Sciences - 29 Dec 1997

Knudson A G

Abstract excerpt

Both hereditary and environmental factors influence the risk of cancer. Four risk categories, or oncodemes, can exist for a particular kind of cancer, depending upon the presence of neither, one, or both factors: (1) spontaneous, or background; (2) hereditary; (3) environmental; (4) interactive....

Topics

Alleles
Carcinoma
Chromosome Mapping
Cloning, Molecular
DNA Repair
Environment
Genes, Dominant
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Humans
Mutation
Neoplasms
Oncogenes

Precancerous Conditions

Puberty

Risk Factors

Selection, Genetic

Stem Cells

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