Processing and secretion of lysosomal acid alpha-glucosidase in Tetrahymena wild type and secretion-deficient mutant cells.

doi:10.1111/j.1550-7408.1993.tb04944.x

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Article

Processing and secretion of lysosomal acid alpha-glucosidase in Tetrahymena wild type and secretion-deficient mutant cells.

The Journal of eukaryotic microbiology - 1 Jan 2000

Banno Y, Okano Y, Furukawa K, Tiedtke A, Kobata A, Nozawa Y

Abstract excerpt

The proteolytic processing and secretion of a lysosomal enzyme, acid alpha-glucosidase, was studied by pulse-chase labeling with [35S]methionine in Tetrahymena thermophila CU-399 cells treated with ammonium chloride. This cell secreted a large amount of acid alpha-glucosidase into the cultured me...

Topics

Ammonium Chloride
Animals
Carbohydrate Sequence
Carbohydrates
Glucan 1,4-alpha-Glucosidase
Molecular Sequence Data
Mutation
Protein Processing, Post-Translational
Tetrahymena

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