Deficiency in lysosomal enzyme secretion is associated with upregulation of phosphatidylinositol 4-phosphate in tetrahymena.

doi:10.1111/j.1550-7408.2008.00329.x

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Article

Deficiency in lysosomal enzyme secretion is associated with upregulation of phosphatidylinositol 4-phosphate in tetrahymena.

The Journal of eukaryotic microbiology - 1 Jan 2000

Deli Dimitra, Leondaritis George, Tiedtke Arno, Galanopoulou Dia

Abstract excerpt

A variety of lower eukaryotes and certain mammalian cells are known to constitutively secrete lysosomal hydrolases. Recent studies in Tetrahymena have shown that phosphatidylinositol 3-phosphate regulates the proper secretion of lysosomal enzymes at the level of phagolysosome formation. We extend these findings by studying the secretion-deficient strain MS-1 of Tetrahymena thermophila, which possess...

Topics

Acid Phosphatase
Androstadienes
Animals
Chromatography, Thin Layer
Lysosomes
Mutation
Phosphatidylinositol Phosphates
Phosphodiesterase Inhibitors
Tetrahymena
Type C Phospholipases
Up-Regulation
Wortmannin

Source

Open in PubMed

Identifiers

PMID: 18681848
DOI: 10.1111/j.1550-7408.2008.00329.x

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