Article
Secondary V(D)J rearrangements and B cell receptor-mediated down-regulation of recombination activating gene-2 expression in a murine B cell line.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2000
Maës J, Caspi Y, Rougeon F, Haimovich J, Goodhardt M
Abstract excerpt
It has recently become clear that recombination of Ig genes is not restricted to B cell precursors but that secondary rearrangements can also occur under certain conditions in phenotypically immature bone marrow and peripheral B cells. However, the nature of these cells and the regulation of secondary V(D)J recombination in response to B cell receptor (BCR) stimulation remain controversial. In the present study,...
Topics
- Animals
- Antibody Diversity
- B-Lymphocytes
- Cell Line
- DNA-Binding Proteins
- Down-Regulation
- Gene Expression Regulation
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genetic Variation
- Immunoglobulin Idiotypes
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region