Article
The mutation in fibrinogen Bicêtre II (gamma Asn308-->Lys) does not affect the binding of t-PA and plasminogen to fibrin.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Oct 1993
Grailhe P, Boyer-Neumann C, Haverkate F, Grimbergen J, Larrieu M J, Anglés-Cano E
Abstract excerpt
The aim of this study was to investigate the interactions of t-PA and plasminogen with fibrin derived from an abnormal fibrinogen detected in a 40-year-old male patient who had had an episode of thrombophlebitis with pulmonary embolism. An abnormal fibrinogen was diagnosed on the basis of prolonged thrombin and reptilase times also detected in two other family members. Fibrinogen purified from plasma, in the...
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