Article
The mutation in fibrinogen Bicêtre II (gamma Asn308-->Lys) does not affect the binding of t-PA and plasminogen to fibrin.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Oct 1993
Grailhe P, Boyer-Neumann C, Haverkate F, Grimbergen J, Larrieu M J, Anglés-Cano E
Abstract excerpt
The aim of this study was to investigate the interactions of t-PA and plasminogen with fibrin derived from an abnormal fibrinogen detected in a 40-year-old male patient who had had an episode of thrombophlebitis with pulmonary embolism. An abnormal fibrinogen was diagnosed on the basis of prolong...
Topics
- Adult
- Base Sequence
- Electrophoresis, Polyacrylamide Gel
- Fibrin
- Fibrinogens, Abnormal
- Hemostasis
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Plasminogen