Article
Investigation of methylation at Hha I sites using the hypervariable probe M27 beta allows improved clonal analysis in myeloid leukaemia and demonstrates differences in methylation between leukaemic and remission samples.
Leukemia - 1 Jan 1994
Gale R E, Linch D C
Abstract excerpt
The methylation-sensitive enzyme Hha I has been used to assess the differentially methylated patterns on active and inactive X-chromosomes at the DXS255 locus recognized by the hypervariable probe M27 beta. The X-chromosome inactivation ratios obtained from 37 haematologically normal females usin...
Topics
- Acute Disease
- Alleles
- DNA Probes
- Deoxyribonucleases, Type II Site-Specific
- Female
- Gene Expression Regulation, Leukemic
- Heterozygote
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Leukemia, Myeloid
- Methylation
- Phosphoglycerate Kinase
- X Chromosome